Hey everyone. My name isRich. This is my first top 10 so bare with me.
Top 10 Game- changing combos; combos that give you a major advantage

10. Lava Golem+Nightmare Wheel+Mask of Restrict
          Perfect combo for burn decks. Special summon LG, equip it w/ the Wheel and activate Mask. Sit back for a turn while your opponent takes 1500 lp .
9. Manticore of Darkness x2+ Card of Safe Return
          This combo's only use is in Exodia Decks. Have one Manticore in your graveyard, another in your hand and CoSR face-up. Keep drawing cards till exodia.
8. Butterfly Dagger-Elma+Gearfried the Iron Knight+Royal Magical Library
          Another Exodia combo that many people tend to stay away from. Have Gearfried and Library on the field and equip Gearfried with the dagger. Keep equiping the dagger to Gearfried , putting counters on Library, and keep drawing cards till Exodia.
7. Magician of Black Chaos x3+Monster Reborn+Painful Choice
          Since the Magician wasn't banned this works. Use Painful Choice to send all 3 magicians to the graveyard; use MR to bring back 1 magician and continue this till you have them all on the field. Then use the last magician to get either raigeki or duster to help clear the field . That's 8400 damage.
6. Ring of D.+Goblin Attack Force+Barrel Behind the door
          Attack w/ Goblin, then use Ring and Barrel so that your opponent takes 6900 damage in one turn.
5. Catapult Turtle+Magical Scientist and the MRD fusions
          1. Get Magical Scientist and Catapult Turtle on the field, with at least 7001 LP left.
          2. Use Magical Scientist's effect (pay 1000 LP to Special Summon a Level 6 or less Fusion from your Fusion deck)        to Special Summon either   Punished Eagle, Roaring Ocean Snake, or Empress Judge (all with 2100 attack).
          3. Launch it with Catapult Turtle (1050 damage).
          4. Repeat until you either win the game or you don't have enough LP to use Scientist. (Under these conditions, you'll launch 7 monsters for 7350 damage)
          5. Launch the Scientist. (7500 total)
          6. Launch the Turtle (8000 total, good game)
4. D.D. Designator+Confiscation/The Forceful Sentry
          Play Confiscation or Sentry to see whats in your opponents hand then play  DDD to get rid of an extra card. You could also use it to git rid of the monster your opponent picked via witch or sangan.
3.Pyramid Turtle+Vampire Lord/Patrician of Darkness/Spirit Reaper +Creature Swap
          Use Creature Swap to give the turtle to your opponent then attack it and get a zombie with an atk of 2000 or less from your deck. Simple.
2. Injection Fairy Lily+Fairy Meteor  Crush+ Life Absorbing Machine
            Equip the meteor to the fairy which = a 3400 trampler and then you gain 1000 lp back next turn.
1. Chaos Emperor Dragon+Witch +Yata
          Have witch on the field when you activate CED and get yata in your hand. I f you didn't summon a mon. for the turn you can play yata and instant lock.

Well this was my Top 10 list.
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See ya!